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High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells

Aging Cell 18(6):e13031

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The maintenance of an electric potential across the inner mitochondrial membrane (negatively charged in the matrix) is necessary to power ATP synthase, and sustained decreases in MMP trigger mitophagy and overall decreases in cell viability [98]